PPIRE18056

Target Protein Information
Protein_Name Cell division control protein 42 homolog
Protein_Sequence MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL
Organism_Source Homo sapiens
Functional_Classification small GTPases
Cellular_Localization Cytoplasm
Gene_Names CDC42
UniProt_ID P60953
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PAK2(71-92)
Peptide_Sequence RPEISPPSDFEHTIHVGFDAVT
Peptide_Length 22
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@H](C(=O)O)[C@@H](C)O)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2451.68
Aliphatic_Index 66.36364
Aromaticity 0.09091
Average_Rotatable_Bonds 3.27273
Charge_at_pH_7 -2.81576
Isoelectric_Point 4.53289
Hydrogen_Bond_Acceptors 34
Hydrogen_Bond_Donors 33
Topological_Polar_Surface_Area 997.43000
X_logP_energy -9.74133
Interaction Information
Affinity KD=0.6 uM
Affinity_Assay fluorescence titration
PDB_ID None
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title Conformation of a Cdc42/Rac Interactive Binding Peptide in Complex with Cdc42 and Analysis of the Binding Interface
Release_Year 1999
PMID 10320322
DOI 10.1021/bi990426u