PPIRE18060

Target Protein Information
Protein_Name Guanine nucleotide-binding protein G(i) subunit alpha-1
Protein_Sequence MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDAARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
Organism_Source Rattus norvegicus
Functional_Classification GTPases
Cellular_Localization Plasma membrane
Gene_Names Gnai1
UniProt_ID P10824
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name R6A
Peptide_Sequence MSQTKRLDDQLYWWEYL
Peptide_Length 17
Peptide_SMILES CSCC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2275.56
Aliphatic_Index 68.82353
Aromaticity 0.23529
Average_Rotatable_Bonds 4.29412
Charge_at_pH_7 -1.00135
Isoelectric_Point 4.37040
Hydrogen_Bond_Acceptors 30
Hydrogen_Bond_Donors 33
Topological_Polar_Surface_Area 927.42000
X_logP_energy -4.49833
Interaction Information
Affinity KD=60 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title In Vitro Selection of State-Specific Peptide Modulators of G Protein Signaling Using mRNA Display
Release_Year 2004
PMID 15248784
DOI 10.1021/bi0498398