PPIRE18065

Target Protein Information
Protein_Name Immunoglobulin heavy constant gamma 1
Protein_Sequence ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIIPDYRNMIGQGA
Organism_Source Homo sapiens
Functional_Classification immunoglobulins
Cellular_Localization Extracellular
Gene_Names IGHG1
UniProt_ID P01857
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name cQFD meditope
Peptide_Sequence CQFDLSTRRLKC
Peptide_Length 12
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CS)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method side chain-side chain cyclization; C1<-->C12; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1469.74
Aliphatic_Index 65.00000
Aromaticity 0.08333
Average_Rotatable_Bonds 4.16667
Charge_at_pH_7 1.87418
Isoelectric_Point 8.82805
Hydrogen_Bond_Acceptors 22
Hydrogen_Bond_Donors 26
Topological_Polar_Surface_Area 654.09000
X_logP_energy -7.30556
Interaction Information
Affinity KD=430 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID 4GW1
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies
Release_Year 2013
PMID 24101516
DOI 10.1073/pnas.1307309110