PPIRE18066

Target Protein Information
Protein_Name Immunoglobulin heavy constant gamma 1
Protein_Sequence ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIIPDYRNMIGQGA
Organism_Source Homo sapiens
Functional_Classification immunoglobulins
Cellular_Localization Extracellular
Gene_Names IGHG1
UniProt_ID P01857
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name cQYN meditope
Peptide_Sequence CQYNLSSRALKC
Peptide_Length 12
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method side chain-side chain cyclization; C1<-->C12; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1385.62
Aliphatic_Index 73.33333
Aromaticity 0.08333
Average_Rotatable_Bonds 3.83333
Charge_at_pH_7 1.87289
Isoelectric_Point 8.79809
Hydrogen_Bond_Acceptors 22
Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 618.21000
X_logP_energy -7.83113
Interaction Information
Affinity KD=3.5 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID 4GW5
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies
Release_Year 2013
PMID 24101516
DOI 10.1073/pnas.1307309110