PPIRE18081
Target Protein Information
| Protein_Name | Cysteine-rich protein 1 |
|---|---|
| Protein_Sequence | MPKCPKCNKEVYFAERVTSLGKDWHRPCLKCEKCGKTLTSGGHAEHEGKPYCNHPCYAAMFGPKGFGRGGAESHTFK |
| Organism_Source | Homo sapiens |
| Functional_Classification | LIM double zinc finger proteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | CRIP1 |
| UniProt_ID | P50238 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | B5 |
|---|---|
| Peptide_Sequence | CYDPIWRTCGGGSK |
| Peptide_Length | 14 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CS)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O |
| Chemical_Modification | None |
| Cyclization_Method | side chain-side chain cyclization; C1<-->C9; disulfide bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1542.75 |
|---|---|
| Aliphatic_Index | 27.85714 |
| Aromaticity | 0.14286 |
| Average_Rotatable_Bonds | 3.28571 |
| Charge_at_pH_7 | 0.87333 |
| Isoelectric_Point | 8.22116 |
|---|---|
| Hydrogen_Bond_Acceptors | 23 |
| Hydrogen_Bond_Donors | 25 |
| Topological_Polar_Surface_Area | 634.53000 |
| X_logP_energy | -7.08083 |
Interaction Information
| Affinity | KD=62.5 uM |
|---|---|
| Affinity_Assay | fluorescence-based saturation binding assay |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Identification and Rational Redesign of Peptide Ligands to CRIP1 A Novel Biomarker for Cancers |
| Release_Year | 2008 |
| PMID | 18670594 |
| DOI | 10.1371/journal.pcbi.1000138 |