PPIRE18128

Target Protein Information
Protein_Name Platelet glycoprotein VI
Protein_Sequence MSPSPTALFCLGLCLGRVPAQSGPLPKPSLQALPSSLVPLEKPVTLRCQGPPGVDLYRLEKLSSSRYQDQAVLFIPAMKRSLAGRYRCSYQNGSLWSLPSDQLELVATGVFAKPSLSAQPGPAVSSGGDVTLQCQTRYGFDQFALYKEGDPAPYKNPERWYRASFPIITVTAAHSGTYRCYSFSSRDPYLWSAPSDPLELVVTGTSVTPSRLPTEPPSPVAEFSEATAELTVSFTNEVFTTETSRSITASPKESDSPAGPARQYYTKGNLVRICLGAVILIILAGFLAEDWHSRRKRLRHRGRAVQRPLPPLPPLPLTRKSNGGQDGGRQDVHSRGLCS
Organism_Source Homo sapiens
Functional_Classification immunoglobulin receptors
Cellular_Localization Plasma membrane
Gene_Names GP6
UniProt_ID Q9HCN6
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name pep-10L
Peptide_Sequence YSDTDWLYFSTS
Peptide_Length 12
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1484.54
Aliphatic_Index 32.50000
Aromaticity 0.33333
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 -2.00282
Isoelectric_Point 3.49188
Hydrogen_Bond_Acceptors 22
Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 615.42000
X_logP_energy -5.67160
Interaction Information
Affinity KD=57 uM
Affinity_Assay NMR chemical shift perturbation
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structure-Based Approach To Improve a Small-Molecule Inhibitor by the Use of a Competitive Peptide Ligand
Release_Year 2014
PMID 24481871
DOI 10.1002/anie.201310749