PPIRE18137

Target Protein Information
Protein_Name None
Protein_Sequence MGLFLPLEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
Organism_Source Gallus gallus
Functional_Classification EF hand calcium binding proteins
Cellular_Localization Cytoplasm
Gene_Names CALM1
UniProt_ID A0A8V0YVM4
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name smMLCKp
Peptide_Sequence GSARRKWQKTGHAVRAIGRLS
Peptide_Length 21
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)CN)[C@@H](C)O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2335.70
Aliphatic_Index 65.23810
Aromaticity 0.04762
Average_Rotatable_Bonds 3.80952
Charge_at_pH_7 6.08829
Isoelectric_Point 12.98470
Hydrogen_Bond_Acceptors 33
Hydrogen_Bond_Donors 42
Topological_Polar_Surface_Area 1093.21000
X_logP_energy -13.57182
Interaction Information
Affinity KD=1 nM
Affinity_Assay binding assay
PDB_ID 1CDL
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Redistribution and loss of side chain entropy upon formation of a calmodulin-peptide complex
Release_Year 2000
PMID 10625431
DOI 10.1038/71280