PPIRE18146
Target Protein Information
| Protein_Name | None |
|---|---|
| Protein_Sequence | MENITSGFLGPLLVLQAGFFWLTRILTIPQSLDSWWTSLNFLGGTTVCLGQNSQSPTSNHSPTSCPPTCPGYRWMCLRRFIIFLFILLLCLIFLLVLLDYQGMLPVCPLIPGSSTTSTGPCRTCTTPAQGTSMYPSCCCTKPSDGNCTCIPIPSSWAFGKFLWEWASARFSWLSLLVPFVQWFVGLSPTVWLSVIWMMWYWGPSLYSILSPFLPLLPIFFCLWVYI |
| Organism_Source | Hepatitis B virus |
| Functional_Classification | viral envelope proteins |
| Cellular_Localization | Extracellular |
| Gene_Names | S gene subtype ayw2 |
| UniProt_ID | Q69601 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | P1 |
|---|---|
| Peptide_Sequence | HWGNHSKSHPQR |
| Peptide_Length | 12 |
| Peptide_SMILES | N=C(N)NCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1470.57 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.08333 |
| Average_Rotatable_Bonds | 3.75000 |
| Charge_at_pH_7 | 2.27041 |
| Isoelectric_Point | 11.65182 |
|---|---|
| Hydrogen_Bond_Acceptors | 22 |
| Hydrogen_Bond_Donors | 24 |
| Topological_Polar_Surface_Area | 691.02000 |
| X_logP_energy | -8.99213 |
Interaction Information
| Affinity | KD=141.22 uM |
|---|---|
| Affinity_Assay | Isothermal Titration Calorimetry |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Blocking peptides against HBV: PreS1 protein selected from a phage display library |
| Release_Year | 2011 |
| PMID | 21856287 |
| DOI | 10.1016/j.bbrc.2011.08.014 |