PPIRE18175

Target Protein Information
Protein_Name None
Protein_Sequence MGLFLPLEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
Organism_Source Gallus gallus
Functional_Classification EF hand calcium binding proteins
Cellular_Localization Cytoplasm
Gene_Names CALM1
UniProt_ID A0A8V0YVM4
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Indolicidin
Peptide_Sequence ILPWKWPWWPWRR
Peptide_Length 13
Peptide_SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1907.30
Aliphatic_Index 60.00000
Aromaticity 0.38462
Average_Rotatable_Bonds 3.69231
Charge_at_pH_7 2.99768
Isoelectric_Point 12.51648
Hydrogen_Bond_Acceptors 17
Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 614.92000
X_logP_energy 4.10224
Interaction Information
Affinity KD=211 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Over-expression of antimicrobial anticancer and transmembrane peptides in Escherichia coli through a calmodulin-peptide fusion system
Release_Year 2016
PMID 27502305
DOI 10.1021/jacs.6b06781