PPIRE18176

Target Protein Information
Protein_Name None
Protein_Sequence MGLFLPLEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
Organism_Source Gallus gallus
Functional_Classification EF hand calcium binding proteins
Cellular_Localization Cytoplasm
Gene_Names CALM1
UniProt_ID A0A8V0YVM4
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Melittin
Peptide_Sequence GIGAVLKVLTTGLPALISWIKRKRQQ
Peptide_Length 26
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)O)C(C)C)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2847.49
Aliphatic_Index 135.00000
Aromaticity 0.03846
Average_Rotatable_Bonds 3.73077
Charge_at_pH_7 4.99709
Isoelectric_Point 12.54608
Hydrogen_Bond_Acceptors 37
Hydrogen_Bond_Donors 41
Topological_Polar_Surface_Area 1146.55000
X_logP_energy -8.48436
Interaction Information
Affinity KD=35 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Over-expression of antimicrobial anticancer and transmembrane peptides in Escherichia coli through a calmodulin-peptide fusion system
Release_Year 2016
PMID 27502305
DOI 10.1021/jacs.6b06781