PPIRE18179

Target Protein Information
Protein_Name None
Protein_Sequence MGLFLPLEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
Organism_Source Gallus gallus
Functional_Classification EF hand calcium binding proteins
Cellular_Localization Cytoplasm
Gene_Names CALM1
UniProt_ID A0A8V0YVM4
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Fowlicidin-1
Peptide_Sequence RVKRVWPLVIRTVIAGYNLYRAIKKK
Peptide_Length 26
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3141.89
Aliphatic_Index 127.30769
Aromaticity 0.11538
Average_Rotatable_Bonds 4.03846
Charge_at_pH_7 7.99509
Isoelectric_Point 12.13060
Hydrogen_Bond_Acceptors 39
Hydrogen_Bond_Donors 47
Topological_Polar_Surface_Area 1253.28000
X_logP_energy -6.00392
Interaction Information
Affinity KD=427 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Over-expression of antimicrobial anticancer and transmembrane peptides in Escherichia coli through a calmodulin-peptide fusion system
Release_Year 2016
PMID 27502305
DOI 10.1021/jacs.6b06781