PPIRE18181
Target Protein Information
| Protein_Name | beta-lactamase |
|---|---|
| Protein_Sequence | TDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGER |
| Organism_Source | Escherichia coli |
| Functional_Classification | serine beta lactamases |
| Cellular_Localization | Extracellular |
| Gene_Names | blaTEM-1 |
| UniProt_ID | A0A088FSW7 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | BP46-51 |
|---|---|
| Peptide_Sequence | CAAGDYYC |
| Peptide_Length | 8 |
| Peptide_SMILES | C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CS)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | Side chain-side chain cyclization; C1<-->C8; disulfide bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 864.94 |
|---|---|
| Aliphatic_Index | 25.00000 |
| Aromaticity | 0.25000 |
| Average_Rotatable_Bonds | 2.87500 |
| Charge_at_pH_7 | -1.12722 |
| Isoelectric_Point | 3.74995 |
|---|---|
| Hydrogen_Bond_Acceptors | 14 |
| Hydrogen_Bond_Donors | 14 |
| Topological_Polar_Surface_Area | 344.78000 |
| X_logP_energy | -3.30600 |
Interaction Information
| Affinity | Ki=603 uM |
|---|---|
| Affinity_Assay | Enzyme Inhibition Kinetics |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Binding Properties of a Peptide Derived from Beta-Lactamase Inhibitory Protein |
| Release_Year | 2001 |
| PMID | 11709298 |
| DOI | 10.1128/AAC.45.12.3279-3286.2001 |