PPIRE18196

Target Protein Information
Protein_Name G-protein coupled receptor Mth
Protein_Sequence MKTLLVLRISTVILVVLVIQKSYADILECDYFDTVDISAAQKLQNGSYLFEGLLVPAILTGEYDFRILPDDSKQKVARHIRGCVCKLKPCVRFCCPHDHIMDNGVCYDNMSDEELAELDPFLNVTLDDGSVSRRHFKNELIVQWDLPMPCDGMFYLDNREEQDKYTLFENGTFFRHFDRVTLRKREYCLQHLTFADGNATSIRIAPHNCLIVPSITGQTVVMISSLICMVLTIAVYLFVKKLQNLHGKCFICYMVCLFMGYLFLLLDLWQISISFCKPAGFLGYFFVMAAFFWLSVISLHLWNTFRGSSHKANRFLFEHRFLAYNTYAWGMAVVLTGITVLADNIVENQDWNPRVGHEGHCWIYTQAWSAMLYFYGPMVFLIAFNITMFILTAKRILGVKKDIQNFAHRQERKQKLNSDKQTYTFFLRLFIIMGLSWSLEIGSYFSQSNQTWANVFLVADYLNWSQGIIIFILFVLKRSTWRLLQESIRGEGEEVNNSEEEISLENTTTRNVLL
Organism_Source Drosophila melanogaster
Functional_Classification G protein-coupled receptor
Cellular_Localization Extracellular
Gene_Names mth
UniProt_ID O97148
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name W5K
Peptide_Sequence FPSSKLQRYYLAKRR
Peptide_Length 15
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1913.26
Aliphatic_Index 58.66667
Aromaticity 0.20000
Average_Rotatable_Bonds 4.20000
Charge_at_pH_7 4.99568
Isoelectric_Point 11.60035
Hydrogen_Bond_Acceptors 26
Hydrogen_Bond_Donors 31
Topological_Polar_Surface_Area 823.68000
X_logP_energy -6.75899
Interaction Information
Affinity KD=1 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID 2PZX
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title The Predicted Binding Site and Dynamics of Peptide Inhibitors to the Methuselah GPCR from Drosophila melanogaster
Release_Year 2008
PMID 18991399
DOI 10.1021/bi801335p