PPIRE18202

Target Protein Information
Protein_Name Acetylcholine receptor subunit alpha
Protein_Sequence MILCSYWHVGLVLLLFSCCGLVLGSEHETRLVANLLENYNKVIRPVEHHTHFVDITVGLQLIQLISVDEVNQIVETNVRLRQQWIDVRLRWNPADYGGIKKIRLPSDDVWLPDLVLYNNADGDFAIVHMTKLLLDYTGKIMWTPPAIFKSYCEIIVTHFPFDQQNCTMKLGIWTYDGTKVSISPESDRPDLSTFMESGEWVMKDYRGWKHWVYYTCCPDTPYLDITYHFIMQRIPLYFVVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMIFVISSIIITVVVINTHHRSPSTHTMPQWVRKIFIDTIPNVMFFSTMKRASKEKQENKIFADDIDISDISGKQVTGEVIFQTPLIKNPDVKSAIEGVKYIAEHMKSDEESSNAAEEWKYVAMVIDHILLCVFMLICIIGTVSVFAGRLIELSQEG
Organism_Source Tetronarce californica
Functional_Classification ligand gated ion channels
Cellular_Localization Plasma membrane
Gene_Names CHRNA1
UniProt_ID P02710
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Torpedo californica nAChR Alpha1 18-mer
Peptide_Sequence YRGWKHWVYYTCCPDTPY
Peptide_Length 18
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification homoserine lactone
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2338.64
Aliphatic_Index 16.11111
Aromaticity 0.33333
Average_Rotatable_Bonds 3.44444
Charge_at_pH_7 0.96169
Isoelectric_Point 8.20895
Hydrogen_Bond_Acceptors 31
Hydrogen_Bond_Donors 33
Topological_Polar_Surface_Area 847.30000
X_logP_energy -3.36513
Interaction Information
Affinity KD=65 nM
Affinity_Assay binding assay
PDB_ID 1LXG
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title NMR-based Binding Screen and Structural Analysis of the Complex Formed between Alpha-Cobratoxin and an 18-Mer Cognate Peptide Derived from the Alpha1 Subunit of the Nicotinic Acetylcholine Receptor from Torpedo californica
Release_Year 2002
PMID 12133834
DOI 10.1074/jbc.M205483200