PPIRE18245
Target Protein Information
| Protein_Name | None |
|---|---|
| Protein_Sequence | ELTQPHSVSESPGKTVTISCTRSSDSIASNYVQWYQRRPGSAPTTVIFADDRRPSGVPDRFSASIDYSSNSASLTISGLRTEDEADYYCQSYDSNNLWVFGGGTKLTVLGQP |
| Organism_Source | Homo sapiens |
| Functional_Classification | immunoglobulins |
| Cellular_Localization | Extracellular |
| Gene_Names | IGLV |
| UniProt_ID | A2KUC4 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Ac-QfHppp-OH |
|---|---|
| Peptide_Sequence | QfHppp |
| Peptide_Length | 6 |
| Peptide_SMILES | NC(=O)CC[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Acetyl |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 721.81 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.16667 |
| Average_Rotatable_Bonds | 2.50000 |
| Charge_at_pH_7 | 0.08889 |
| Isoelectric_Point | 7.55032 |
|---|---|
| Hydrogen_Bond_Acceptors | 9 |
| Hydrogen_Bond_Donors | 6 |
| Topological_Polar_Surface_Area | 254.22000 |
| X_logP_energy | -1.18510 |
Interaction Information
| Affinity | KD=14.49 uM |
|---|---|
| Affinity_Assay | spectrophotometric titration |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Principles and pitfalls in designing site-directed peptide ligands |
| Release_Year | 1993 |
| PMID | 8346191 |
| DOI | 10.1002/prot.340160304 |