PPIRE18281

Target Protein Information
Protein_Name Major prion protein
Protein_Sequence MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
Organism_Source Homo sapiens
Functional_Classification prion proteins
Cellular_Localization Plasma membrane
Gene_Names PRNP
UniProt_ID P04156
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide 149YYRENMHRYPNQ160
Peptide_Sequence YYRENMHRYPNQ
Peptide_Length 12
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1670.82
Aliphatic_Index 0.00000
Aromaticity 0.25000
Average_Rotatable_Bonds 4.25000
Charge_at_pH_7 1.08811
Isoelectric_Point 9.06895
Hydrogen_Bond_Acceptors 24
Hydrogen_Bond_Donors 26
Topological_Polar_Surface_Area 754.37000
X_logP_energy -6.79126
Interaction Information
Affinity KD=140 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Peptide NMHRYPNQ of the Cellular Prion Protein (PrP C) Inhibits Aggregation and Is a Potential Key for Understanding Prion-鍌欒兌閸嬨劑宕曢懠韬蹭汗濠靛壘on Interactions
Release_Year 2009
PMID 19607841
DOI 10.1016/j.jmb.2009.07.014