PPIRE18291
Target Protein Information
| Protein_Name | Probable non-functional immunoglobulin heavy variable 3-38-3 |
|---|---|
| Protein_Sequence | MQFVLSWVFLVAILKGVQCEVQLVESRGVLVQPGGSLRLSCAASGFTVSSNEMSWVRQAPGKGLEWVSSISGGSTYYADSRKGRFTISRDNSKNTLHLQMNSLRAEDTAVYYCKK |
| Organism_Source | Homo sapiens |
| Functional_Classification | antibody fragment |
| Cellular_Localization | Extracellular |
| Gene_Names | IGHV3-38-3 |
| UniProt_ID | P0DTE1 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Peptide_23 |
|---|---|
| Peptide_Sequence | PKARRPEGRTWAQPG |
| Peptide_Length | 15 |
| Peptide_SMILES | C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)[C@@H](C)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1706.93 |
|---|---|
| Aliphatic_Index | 13.33333 |
| Aromaticity | 0.06667 |
| Average_Rotatable_Bonds | 3.46667 |
| Charge_at_pH_7 | 2.99945 |
| Isoelectric_Point | 12.22264 |
|---|---|
| Hydrogen_Bond_Acceptors | 23 |
| Hydrogen_Bond_Donors | 28 |
| Topological_Polar_Surface_Area | 767.28000 |
| X_logP_energy | -8.92089 |
Interaction Information
| Affinity | IC50=10 uM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Human recombinant antibodies specific for hepatitis C virus core and envelope E2 peptides from an immune phage display library |
| Release_Year | 1996 |
| PMID | 8887487 |
| DOI | 10.1099/0022-1317-77-10-2531 |