PPIRE18315

Target Protein Information
Protein_Name Dynein light chain 1 cytoplasmic
Protein_Sequence MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG
Organism_Source Homo sapiens
Functional_Classification Adaptor scaffold proteins
Cellular_Localization Cytoplasm
Gene_Names DYNLL1
UniProt_ID P63167
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name DNBLK1
Peptide_Sequence RRRRRRRRHPAEPGSTVTTQNTASQTMS
Peptide_Length 28
Peptide_SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3294.67
Aliphatic_Index 17.50000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.92857
Charge_at_pH_7 7.09064
Isoelectric_Point 12.97713
Hydrogen_Bond_Acceptors 51
Hydrogen_Bond_Donors 64
Topological_Polar_Surface_Area 1683.73000
X_logP_energy -27.19534
Interaction Information
Affinity EC50=20 uM
Affinity_Assay immunofluorescence assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Small Peptide Inhibitors Disrupt a High-Affinity Interaction between Cytoplasmic Dynein and a Viral Cargo Protein
Release_Year 2010
PMID 20686048
DOI 10.1128/JVI.01168-10