PPIRE18363

Target Protein Information
Protein_Name Acetylcholine receptor subunit alpha
Protein_Sequence MILCSYWHVGLVLLLFSCCGLVLGSEHETRLVANLLENYNKVIRPVEHHTHFVDITVGLQLIQLINVDEVNQIVETNVRLRQQWIDVRLRWNPADYGGIKKIRLPSDDVWLPDLVLYNNADGDFAIVHMTKLLLDYTGKIMWTPPAIFKSYCEIIVTHFPFDQQNCTMKLGIWTYDGTKVSISPESDRPDLSTFMESGEWVMKDYRGWKHWVYYTCCPDTPYLDITYHFIMQRIPLYFVVNVIIPCLLFSFLTVLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMIFVISSIIVTVVVINTHHRSPSTHTMPQWVRKIFINTIPNVMFFSTMKRASKEKQENKIFADDIDISDISGKQVTGEVIFQTPLIKNPDVKSAIEGVKYIAEHMKSDEESSNAAEEWKYVAMVIDHILLCVFMLICIIGTVSVFAGRLIELSQEG
Organism_Source Torpedo marmorata
Functional_Classification ligand gated ion channels
Cellular_Localization Plasma membrane
Gene_Names CHRNA1
UniProt_ID P02711
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Human_R7_187-200
Peptide_Sequence ERFYECCKEPYPD
Peptide_Length 13
Peptide_SMILES N=C(N)NCCC[C@H](NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1678.85
Aliphatic_Index 0.00000
Aromaticity 0.23077
Average_Rotatable_Bonds 3.84615
Charge_at_pH_7 -2.12219
Isoelectric_Point 4.14752
Hydrogen_Bond_Acceptors 24
Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 672.52000
X_logP_energy -4.31143
Interaction Information
Affinity IC50=200 uM
Affinity_Assay ELISA
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Mimotopes of the Nicotinic Receptor Binding Site Selected by a Combinatorial Peptide Library
Release_Year 2001
PMID 11380255
DOI 10.1021/bi0023201