PPIRE18365

Target Protein Information
Protein_Name Acetylcholine receptor subunit alpha
Protein_Sequence MILCSYWHVGLVLLLFSCCGLVLGSEHETRLVANLLENYNKVIRPVEHHTHFVDITVGLQLIQLINVDEVNQIVETNVRLRQQWIDVRLRWNPADYGGIKKIRLPSDDVWLPDLVLYNNADGDFAIVHMTKLLLDYTGKIMWTPPAIFKSYCEIIVTHFPFDQQNCTMKLGIWTYDGTKVSISPESDRPDLSTFMESGEWVMKDYRGWKHWVYYTCCPDTPYLDITYHFIMQRIPLYFVVNVIIPCLLFSFLTVLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMIFVISSIIVTVVVINTHHRSPSTHTMPQWVRKIFINTIPNVMFFSTMKRASKEKQENKIFADDIDISDISGKQVTGEVIFQTPLIKNPDVKSAIEGVKYIAEHMKSDEESSNAAEEWKYVAMVIDHILLCVFMLICIIGTVSVFAGRLIELSQEG
Organism_Source Torpedo marmorata
Functional_Classification ligand gated ion channels
Cellular_Localization Plasma membrane
Gene_Names CHRNA1
UniProt_ID P02711
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Phage_library_peptide
Peptide_Sequence MRYYESSLKSYPD
Peptide_Length 13
Peptide_SMILES CSCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1638.81
Aliphatic_Index 30.00000
Aromaticity 0.23077
Average_Rotatable_Bonds 3.92308
Charge_at_pH_7 -0.00264
Isoelectric_Point 6.47452
Hydrogen_Bond_Acceptors 25
Hydrogen_Bond_Donors 25
Topological_Polar_Surface_Area 687.63000
X_logP_energy -5.92513
Interaction Information
Affinity IC50=3.86 uM
Affinity_Assay ELISA
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Mimotopes of the Nicotinic Receptor Binding Site Selected by a Combinatorial Peptide Library
Release_Year 2001
PMID 11380255
DOI 10.1021/bi0023201