PPIRE18374

Target Protein Information
Protein_Name Ig gamma-1 chain C region secreted form/Immunoglobulin kappa constant
Protein_Sequence AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMNTNGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK/RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
Organism_Source Mus musculus/Homo sapiens
Functional_Classification antibodies
Cellular_Localization Extracellular
Gene_Names Ighg1/IGKC
UniProt_ID P01868/P01834
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Randomized myc-tag variant
Peptide_Sequence TMFLISEEDLQ
Peptide_Length 11
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1325.50
Aliphatic_Index 106.36364
Aromaticity 0.09091
Average_Rotatable_Bonds 4.09091
Charge_at_pH_7 -2.99802
Isoelectric_Point 3.42471
Hydrogen_Bond_Acceptors 19
Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 549.77000
X_logP_energy -3.77670
Interaction Information
Affinity KD=1.2 uM
Affinity_Assay ELISA
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Anti-c-myc antibody 9E10: epitope key positions and variability characterized using peptide spot synthesis on cellulose
Release_Year 2001
PMID 11739900
DOI 10.1093/protein/14.10.803