PPIRE18375

Target Protein Information
Protein_Name Actin alpha skeletal muscle
Protein_Sequence MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF
Organism_Source Oryctolagus cuniculus
Functional_Classification actins
Cellular_Localization Cytoplasm
Gene_Names ACTA1
UniProt_ID P68135
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name (R/W)16
Peptide_Sequence RRWRRWWRRWWRRWRR
Peptide_Length 16
Peptide_SMILES N=C(N)NCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification biotinyl-Apa
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2697.17
Aliphatic_Index 0.00000
Aromaticity 0.37500
Average_Rotatable_Bonds 5.18750
Charge_at_pH_7 9.99795
Isoelectric_Point 13.45425
Hydrogen_Bond_Acceptors 27
Hydrogen_Bond_Donors 53
Topological_Polar_Surface_Area 1213.56000
X_logP_energy -5.35300
Interaction Information
Affinity KD=0.4 uM
Affinity_Assay Isothermal Titration Calorimetry
PDB_ID None
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title Cell-penetrating Peptides with Intracellular Actin-remodeling Activity in Malignant Fibroblasts
Release_Year 2010
PMID 20037163
DOI 10.1074/jbc.M109.045872