PPIRE18376

Target Protein Information
Protein_Name Actin alpha skeletal muscle
Protein_Sequence MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF
Organism_Source Oryctolagus cuniculus
Functional_Classification actins
Cellular_Localization Cytoplasm
Gene_Names ACTA1
UniProt_ID P68135
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name (R/W)9
Peptide_Sequence XXkCRRWWRRWRR
Peptide_Length 13
Peptide_SMILES N=C(N)NCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CN)C(=O)O
Chemical_Modification X1=N-trifluoroacetyl((cid:3)-(cid:3)-diethyl)glycine; X2=Lys(N-biotin)
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification trifluoroacetyl((cid:3)-(cid:3)-diethyl)Gly-Lys(N-biotin)
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1859.20
Aliphatic_Index 0.00000
Aromaticity 0.23077
Average_Rotatable_Bonds 4.61538
Charge_at_pH_7 6.93569
Isoelectric_Point 12.80426
Hydrogen_Bond_Acceptors 22
Hydrogen_Bond_Donors 37
Topological_Polar_Surface_Area 857.31000
X_logP_energy -6.71088
Interaction Information
Affinity KD=10 uM
Affinity_Assay Isothermal Titration Calorimetry
PDB_ID None
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title Cell-penetrating Peptides with Intracellular Actin-remodeling Activity in Malignant Fibroblasts
Release_Year 2010
PMID 20037163
DOI 10.1074/jbc.M109.045872