PPIRE18381

Target Protein Information
Protein_Name Nociceptin receptor
Protein_Sequence MESLFPAPYWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASSLHREMQVSDRVRSIAKDVGLGCKTSETVPRPA
Organism_Source Rattus norvegicus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names Oprl1
UniProt_ID P35370
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name N/OFQ
Peptide_Sequence FGGFTGARKSARKLANQ
Peptide_Length 17
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1809.06
Aliphatic_Index 40.58824
Aromaticity 0.11765
Average_Rotatable_Bonds 3.64706
Charge_at_pH_7 3.99739
Isoelectric_Point 12.53175
Hydrogen_Bond_Acceptors 26
Hydrogen_Bond_Donors 30
Topological_Polar_Surface_Area 831.40000
X_logP_energy -11.06096
Interaction Information
Affinity IC50=26 nM
Affinity_Assay Patch-clamp electrophysiology
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Nociceptin/orphanin FQ peptide receptor mediates inhibition of N-type calcium currents in vestibular afferent neurons of the rat
Release_Year 2020
PMID 32966754
DOI 10.1152/jn.00269.2020