PPIRE18383

Target Protein Information
Protein_Name B-cell lymphoma/leukemia 10
Protein_Sequence MEPTAPSLTEEDLTEVKKDALENLRVYLCEKIIAERHFDHLRAKKILSREDTEEISCRTSSRKRAGKLLDYLQENPKGLDTLVESIRREKTQNFLIQKITDEVLKLRNIKLEHLKGLKCSSCEPFPDGATNNLSRSNSDESNFSEKLRASTVMYHPEGESSTTPFFSTNSSLNLPVLEVGRTENTIFSSTTLPRPGDPGAPPLPPDLQLEEEGTCANSSEMFLPLRSRTVSRQ
Organism_Source Homo sapiens
Functional_Classification CARD containing adaptors
Cellular_Localization Cytoplasm
Gene_Names BCL10
UniProt_ID O95999
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Tat 10-(91-98)
Peptide_Sequence GRKKRRQRRRPPQXXTQNFLIQK
Peptide_Length 23
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification X14=Beta-alanine; X15=Beta-alanine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2806.28
Aliphatic_Index 33.91304
Aromaticity 0.04348
Average_Rotatable_Bonds 4.34783
Charge_at_pH_7 8.99708
Isoelectric_Point 13.20514
Hydrogen_Bond_Acceptors 39
Hydrogen_Bond_Donors 49
Topological_Polar_Surface_Area 1371.08000
X_logP_energy -17.40978
Interaction Information
Affinity IC50=5 uM
Affinity_Assay co-immunoprecipitation
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Generation and functional characterization of a BCL10-inhibitory peptide that represses NF-KappaB activation
Release_Year 2009
PMID 19538180
DOI 10.1042/BJ20090055