PPIRE18392

Target Protein Information
Protein_Name Immunoglobulin heavy constant gamma 1
Protein_Sequence ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIIPDYRNMIGQGA
Organism_Source Homo sapiens
Functional_Classification IgG1 antibodies
Cellular_Localization Extracellular
Gene_Names IGHG1
UniProt_ID P01857
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name P02-C01
Peptide_Sequence RDYHPRDHTATWGGG
Peptide_Length 15
Peptide_SMILES C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCNC(=N)N)[C@@H](C)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)NCC(=O)NCC(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1725.80
Aliphatic_Index 6.66667
Aromaticity 0.13333
Average_Rotatable_Bonds 3.33333
Charge_at_pH_7 0.17984
Isoelectric_Point 7.70663
Hydrogen_Bond_Acceptors 25
Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 794.17000
X_logP_energy -9.55276
Interaction Information
Affinity KD=104 uM
Affinity_Assay multiple reaction monitoring mass spectrometry binding assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title A new approach to quantification of mAb aggregates using peptide affinity probes
Release_Year 2017
PMID 28186164
DOI 10.1038/srep42497