PPIRE18403

Target Protein Information
Protein_Name Microtubule-associated protein tau
Protein_Sequence MAEPRQEFDVMEDHAQGDYTLQDQEGDMDPGLKESPLQTPADDGSEEPGSETSDAKSTPTAEDATAPLVDEGAPGEQAAAQAPAEIPEGTAAEEAGIGDTSNLEDQAAGHVTQARMVSKGKDGTGPDDKKTKGADGKPGTKIATPRGAAPPGQKGQANATRIPAKTTPTPKTSPATMQVQKKPPPAGAKSERGESGKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSAAKSRLQAAPGPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Organism_Source Bos taurus
Functional_Classification microtubule associated proteins
Cellular_Localization Cytoplasm
Gene_Names MAPT
UniProt_ID P29172
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide_F
Peptide_Sequence PKSGDRSGYSSPGSPGTPG
Peptide_Length 19
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1790.86
Aliphatic_Index 0.00000
Aromaticity 0.05263
Average_Rotatable_Bonds 2.73684
Charge_at_pH_7 0.99728
Isoelectric_Point 9.29736
Hydrogen_Bond_Acceptors 30
Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 813.59000
X_logP_energy -15.61743
Interaction Information
Affinity IC50=36 pM
Affinity_Assay ELISA
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Application of Synthetic Phospho- and Unphospho- Peptides to Identify Phosphorylation Sites in a Subregion of the tau Molecule Which Is Modified in Alzheimer's Disease
Release_Year 1993
PMID 8455212
DOI 10.1002/jnr.490340315