PPIRE18413

Target Protein Information
Protein_Name Cytochrome P450 1B1
Protein_Sequence MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQNLQAKETCQ
Organism_Source Homo sapiens
Functional_Classification cytochrome P450 monooxygenase
Cellular_Localization Extracellular
Gene_Names CYP1B1
UniProt_ID Q16678
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CYP1B1_240
Peptide_Sequence LVDVMPWLQY
Peptide_Length 10
Peptide_SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(C)C)C(C)C)C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1263.52
Aliphatic_Index 136.00000
Aromaticity 0.20000
Average_Rotatable_Bonds 3.60000
Charge_at_pH_7 -1.00242
Isoelectric_Point 3.74999
Hydrogen_Bond_Acceptors 15
Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 432.84000
X_logP_energy 0.83750
Interaction Information
Affinity IC50=1 uM
Affinity_Assay assembly assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Characterization of a single peptide derived from cytochrome P450 1B1 that elicits spontaneous human leukocyte antigen (HLA)-A1 as well as HLA-B35 restricted CD8 T-cell responses in cancer patients
Release_Year 2008
PMID 18486761
DOI 10.1016/j.humimm.2008.02.007