PPIRE18425
Target Protein Information
| Protein_Name | Putative helicase 009L |
|---|---|
| Protein_Sequence | MDTSPYDFLKLYPWLSRGEADKGTLLDAFPGETFEQSLASDVAMRRAVQDDPAFGHQKLVETFLSEDTPYRELLLFHAPGTGKTCTVVSVAERAKEKGLTRGCIVLARGAALLRNFLHELVFNCGTGGRYIPEGYADMGDQERTRKMRKAVSSYYQFRTYETFAKSVATMSAEAIRARYDRFVIVMDEVHHLRSVQAEGVNTYSAISRFLRTVRGCVKMLLTGTPMTNEPGELADVLNLILPQDKTIRPEDGIFSNSGDLLKPDELAERVRGRVSYLKAARPDAGLTFAGEVLGGTGMTHLRLVRLEMSAFQSDAYASAWDQDAGDRNIFSNSRQCSLAVMPDRRWGSAAEARNPSQVRRMAGQNLAEYSVKYDYLVRVASSSPKTFAYCEYVNGSGLSLLSDILLANGWRRATGRETTPGKRFALLTASQKNIHKIVQRFNHEDNVDGAYISLLLGSRVVAEGLTFKEVRHTVILTPHWNYTETAQAIARSWRAGSHDRLKARGEAVAVTVHRLVAVPRGRDTPRSIDSDMYAVSEVKDKRIKAVERILMTSAADCSLLRSRNLYPSEFDGSRECEYGRCAYRCSNVSVEPGPLPALLGASAAEAVAQVRLDGGGDPAIMKVDMSTLWAEVTAGRRYVNRWGDGAVLRAEGGRLELSAPYGSSEEGRWGDFYKTRNLCYAKMDQDHLRADDLRDSLPQEVEELLTVSPVETIGETASAMPQEVATAILMACVQARADGKTLNVVRRDALLDFYKGFYAMGPSGWTVWLHARGANAKVYDGRRWNPADEDTLEFLAARSAKFTDTRIGYYGLYNPNLKDFCIRDVTQGKRDKVDLRKLTVGRRCVDWDQRTLVHIVARLMKIDGRRDFMPHATLREMRELAEQDPLHEPSDLTSKEACRRFLFWTQKGDNKFRRQDICKAMEKWFIENDLMEDNFDCGHQHKRRGKFA |
| Organism_Source | Frog virus 3 (isolate Goorha) |
| Functional_Classification | G protein-coupled receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | None |
| UniProt_ID | Q6GZW6 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | R-MSH |
|---|---|
| Peptide_Sequence | SYSMEHFRWGKPV |
| Peptide_Length | 13 |
| Peptide_SMILES | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Acetyl |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1623.85 |
|---|---|
| Aliphatic_Index | 22.30769 |
| Aromaticity | 0.23077 |
| Average_Rotatable_Bonds | 3.76923 |
| Charge_at_pH_7 | 1.08952 |
| Isoelectric_Point | 9.29976 |
|---|---|
| Hydrogen_Bond_Acceptors | 22 |
| Hydrogen_Bond_Donors | 23 |
| Topological_Polar_Surface_Area | 634.11000 |
| X_logP_energy | -4.11493 |
Interaction Information
| Affinity | IC50=0.1 nM |
|---|---|
| Affinity_Assay | frog skin bioassay |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Design in Topographical Space of Peptide and Peptidomimetic Ligands That Affect Behavior. A Chemist-鍌欒兌閸嬨劑宕曢弻銉﹀仒 Glimpse at the Mind-Body Problem |
| Release_Year | 2001 |
| PMID | 11352717 |
| DOI | 10.1021/ar990063q |