PPIRE18429
Target Protein Information
| Protein_Name | Putative helicase 009L |
|---|---|
| Protein_Sequence | MDTSPYDFLKLYPWLSRGEADKGTLLDAFPGETFEQSLASDVAMRRAVQDDPAFGHQKLVETFLSEDTPYRELLLFHAPGTGKTCTVVSVAERAKEKGLTRGCIVLARGAALLRNFLHELVFNCGTGGRYIPEGYADMGDQERTRKMRKAVSSYYQFRTYETFAKSVATMSAEAIRARYDRFVIVMDEVHHLRSVQAEGVNTYSAISRFLRTVRGCVKMLLTGTPMTNEPGELADVLNLILPQDKTIRPEDGIFSNSGDLLKPDELAERVRGRVSYLKAARPDAGLTFAGEVLGGTGMTHLRLVRLEMSAFQSDAYASAWDQDAGDRNIFSNSRQCSLAVMPDRRWGSAAEARNPSQVRRMAGQNLAEYSVKYDYLVRVASSSPKTFAYCEYVNGSGLSLLSDILLANGWRRATGRETTPGKRFALLTASQKNIHKIVQRFNHEDNVDGAYISLLLGSRVVAEGLTFKEVRHTVILTPHWNYTETAQAIARSWRAGSHDRLKARGEAVAVTVHRLVAVPRGRDTPRSIDSDMYAVSEVKDKRIKAVERILMTSAADCSLLRSRNLYPSEFDGSRECEYGRCAYRCSNVSVEPGPLPALLGASAAEAVAQVRLDGGGDPAIMKVDMSTLWAEVTAGRRYVNRWGDGAVLRAEGGRLELSAPYGSSEEGRWGDFYKTRNLCYAKMDQDHLRADDLRDSLPQEVEELLTVSPVETIGETASAMPQEVATAILMACVQARADGKTLNVVRRDALLDFYKGFYAMGPSGWTVWLHARGANAKVYDGRRWNPADEDTLEFLAARSAKFTDTRIGYYGLYNPNLKDFCIRDVTQGKRDKVDLRKLTVGRRCVDWDQRTLVHIVARLMKIDGRRDFMPHATLREMRELAEQDPLHEPSDLTSKEACRRFLFWTQKGDNKFRRQDICKAMEKWFIENDLMEDNFDCGHQHKRRGKFA |
| Organism_Source | Frog virus 3 (isolate Goorha) |
| Functional_Classification | G protein-coupled receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | None |
| UniProt_ID | Q6GZW6 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | [(2S-3R)-MeTrp9]MT-II |
|---|---|
| Peptide_Sequence | XdHfRXK |
| Peptide_Length | 7 |
| Peptide_SMILES | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(=O)O)NC(=O)CN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O |
| Chemical_Modification | X1=norleucine; X6=(2S-3R)-2'-6'-dimethyltryptophan |
| Cyclization_Method | Side chain-side chain cyclization; D2<-->K7; amide bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 815.89 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.14286 |
| Average_Rotatable_Bonds | 3.85714 |
| Charge_at_pH_7 | 1.08904 |
| Isoelectric_Point | 9.69702 |
|---|---|
| Hydrogen_Bond_Acceptors | 12 |
| Hydrogen_Bond_Donors | 14 |
| Topological_Polar_Surface_Area | 391.82000 |
| X_logP_energy | -4.35463 |
Interaction Information
| Affinity | IC50=0.06 nM |
|---|---|
| Affinity_Assay | frog skin bioassay |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Design in Topographical Space of Peptide and Peptidomimetic Ligands That Affect Behavior. A Chemist-鍌欒兌閸嬨劑宕曢弻銉﹀仒 Glimpse at the Mind-Body Problem |
| Release_Year | 2001 |
| PMID | 11352717 |
| DOI | 10.1021/ar990063q |