PPIRE18469

Target Protein Information
Protein_Name TGF-beta receptor type-2
Protein_Sequence MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
Organism_Source Homo sapiens
Functional_Classification Serine threonine kinase receptor
Cellular_Localization Plasma membrane
Gene_Names TGFBR2
UniProt_ID P37173
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Pep1
Peptide_Sequence LTGKNFPMFHRN
Peptide_Length 12
Peptide_SMILES CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)CC(C)C)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1461.70
Aliphatic_Index 32.50000
Aromaticity 0.16667
Average_Rotatable_Bonds 3.83333
Charge_at_pH_7 2.08860
Isoelectric_Point 11.65179
Hydrogen_Bond_Acceptors 20
Hydrogen_Bond_Donors 20
Topological_Polar_Surface_Area 597.64000
X_logP_energy -5.35703
Interaction Information
Affinity KD=10 uM
Affinity_Assay ELISA
PDB_ID None
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title Peptide ligands that use a novel binding site to target both TGF-Beta receptors
Release_Year 2010
PMID 20890540
DOI 10.1039/c0mb00115e