PPIRE18470

Target Protein Information
Protein_Name TGF-beta receptor type-1
Protein_Sequence MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
Organism_Source Homo sapiens
Functional_Classification Serine threonine kinase receptor
Cellular_Localization Plasma membrane
Gene_Names TGFBR1
UniProt_ID P36897
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Pep2
Peptide_Sequence MHRMPSFLPTTL
Peptide_Length 12
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1430.75
Aliphatic_Index 65.00000
Aromaticity 0.08333
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 1.08889
Isoelectric_Point 10.55176
Hydrogen_Bond_Acceptors 20
Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 517.11000
X_logP_energy -3.43243
Interaction Information
Affinity KD=10 uM
Affinity_Assay ELISA
PDB_ID None
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title Peptide ligands that use a novel binding site to target both TGF-Beta receptors
Release_Year 2010
PMID 20890540
DOI 10.1039/c0mb00115e