PPIRE18485

Target Protein Information
Protein_Name Tyrosine-protein phosphatase non-receptor type 5
Protein_Sequence MNYEGARSERENHAADDSEGGALDMCCSERLPGLPQPIVMEALDEAEGLQDSQREMPPPPPPSPPSDPAQKPPPRGAGSHSLTVRSSLCLFAASQFLLACGVLWFSGYGHIWSQNATNLVSSLLTLLKQLEPTAWLDSGTWGVPSLLLVFLSVGLVLVTTLVWHLLRTPPEPPTPLPPEDRRQSVSRQPSFTYSEWMEEKIEDDFLDLDPVPETPVFDCVMDIKPEADPTSLTVKSMGLQERRGSNVSLTLDMCTPGCNEEGFGYLMSPREESAREYLLSASRVLQAEELHEKALDPFLLQAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVAYDGVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQLSHQSPE
Organism_Source Homo sapiens
Functional_Classification protein tyrosine phosphatases
Cellular_Localization Cytoplasm
Gene_Names PTPN5
UniProt_ID P54829
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name H-Ser-Ser-Glu-Asn-Phe-Asp-Asp-Tyr(PO3H2)-Met-Lys-NH2
Peptide_Sequence SSENFDDXMK
Peptide_Length 10
Peptide_SMILES CSCC[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification X8=O-phospho-L-tyrosine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1129.16
Aliphatic_Index 0.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 3.90000
Charge_at_pH_7 -1.99964
Isoelectric_Point 3.87601
Hydrogen_Bond_Acceptors 19
Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 546.69000
X_logP_energy -7.80810
Interaction Information
Affinity Km=42 uM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Substrate
Structure
Reference Information
Document_Type Research Articles
Title Synthesis of Phosphotyrosine-Containing Peptides and Their Use as Substrates for Protein Tyrosine Phosphatases
Release_Year 1993
PMID 7683493
DOI 10.1021/bi00068a025