PPIRE18497

Target Protein Information
Protein_Name Proto-oncogene tyrosine-protein kinase Src
Protein_Sequence MGSNKSKPKDASQRRRSLEPSENVHGAGGAFPASQTPSKPASADGHRGPSAAFVPPAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Organism_Source Mus musculus
Functional_Classification tyrosine kinases
Cellular_Localization Cytoplasm
Gene_Names Src
UniProt_ID P05480
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name RR-src
Peptide_Sequence RRLIEDAEYAARG
Peptide_Length 13
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1519.68
Aliphatic_Index 83.07692
Aromaticity 0.07692
Average_Rotatable_Bonds 3.92308
Charge_at_pH_7 0.00112
Isoelectric_Point 6.57925
Hydrogen_Bond_Acceptors 21
Hydrogen_Bond_Donors 27
Topological_Polar_Surface_Area 730.35000
X_logP_energy -7.05839
Interaction Information
Affinity Ki=3 mM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Substrate
Structure
Reference Information
Document_Type Research Articles
Title Modulation of the effector functions of cytolytic T-lymphocytes with synthetic peptide inhibitors of protein kinases
Release_Year 1992
PMID 1619567
DOI 10.1002/jps.2600810108