PPIRE18500
Target Protein Information
| Protein_Name | protein-tyrosine-phosphatase |
|---|---|
| Protein_Sequence | MWFHSHCTALTSSTMPSRSGCTFEEASDPVVPCEFSQAQYDDFQWEQVRIHPGTRTPADLPHGAYLMVNASQHAPGQRAHIIFQTLSENDTHCVQFSYFLFSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDHKGYIGLDDILLFSHPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFFLQRQSGVLVPAAGVRHISHRRFLATFPLASVGRSEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVNLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLLSRTKCAEPTRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYAVSLCYHYTLGGSHNQTIRECVKMERGASRYTIKNLLPFRNVHVRLILTNPEGRKEGKEVTFQTDEDVPGGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLQPGTTYLFSVRARTSKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRPAQGRGAPISVYQVVVEEERPRRLRREPGGQDCFSVPLTFETALARGLVHYFGAELAASSLLEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIIIIRKGKPVNMAKATVNYRQEKTHMMTAVDRSFTDQSTLQEDERLGLSFMDAPGYSPRGDQRSSGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFFEGWDATKKKDKLKSGRQEPVSAYDRHRVKLHPMLGDPDADYISANYIDGYHRSNHFIATQGPKPEMIYDFWRMVWQEQCVSVVMISKLVEVGRVKCSRYWPEDSDMYGDIKITLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPVVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVNEFKATYREMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISSDGDPNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFVSGTANEDLVSRVFRVQNSSRLQEGHLLVRHFQFLRWSAYRDTPDSRKAFLHLLAEVDKWQAESGDGRTVVHCLNGGGRSGTFCACATVLEMIRCHSLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEALELR |
| Organism_Source | Rattus norvegicus |
| Functional_Classification | Hydrolases protein tyrosine phosphatases |
| Cellular_Localization | Cytoplasm |
| Gene_Names | Ptpru |
| UniProt_ID | A0A0G2K3H0 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Dd73C-5mer |
|---|---|
| Peptide_Sequence | RGPGC |
| Peptide_Length | 5 |
| Peptide_SMILES | N=C(N)NCCC[C@H](N)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 488.56 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 2.60000 |
| Charge_at_pH_7 | 0.93601 |
| Isoelectric_Point | 8.54991 |
|---|---|
| Hydrogen_Bond_Acceptors | 8 |
| Hydrogen_Bond_Donors | 9 |
| Topological_Polar_Surface_Area | 232.83000 |
| X_logP_energy | -3.70043 |
Interaction Information
| Affinity | KD=0.0091 uM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | 5WER |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Crystal structure of a TAPBPR-鍌欒兌閸嬨劑宕曢懠韬蹭汗闁革附-I complex reveals the mechanism of peptide editing in antigen presentation |
| Release_Year | 2017 |
| PMID | 29025991 |
| DOI | 10.1126/science.aao5154 |