PPIRE18502

Target Protein Information
Protein_Name Corticotropin-releasing factor receptor 1
Protein_Sequence MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names CRHR1
UniProt_ID P34998
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name cCRF30-41
Peptide_Sequence EAHKNRKLMEII
Peptide_Length 12
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCC(=O)O)[C@@H](C)CC)C(=O)O
Chemical_Modification None
Cyclization_Method side chain-side chain cyclization; E30<-->K33; other bonds
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1481.78
Aliphatic_Index 105.83333
Aromaticity 0.00000
Average_Rotatable_Bonds 4.50000
Charge_at_pH_7 1.09185
Isoelectric_Point 9.53692
Hydrogen_Bond_Acceptors 21
Hydrogen_Bond_Donors 22
Topological_Polar_Surface_Area 643.73000
X_logP_energy -4.26553
Interaction Information
Affinity Ki=545 nM
Affinity_Assay scintillation proximity assay
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Research Articles
Title NMR Structural Characterization of a Minimal Peptide Antagonist Bound to the Extracellular Domain of the Corticotropin-releasing Factor1 Receptor
Release_Year 2007
PMID 17192263
DOI 10.1074/jbc.M609816200