PPIRE18524

Target Protein Information
Protein_Name Lutropin-choriogonadotropic hormone receptor
Protein_Sequence MRRRSLALRLLLALLLLPPPLPQTLLGAPCPEPCSCRPDGALRCPGPRAGLSRLSLTYLPIKVIPSQAFRGLNEVVKIEISQSDSLEKIEANAFDNLLNLSEILIQNTKNLVYIEPGAFTNLPRLKYLSICNTGIRKLPDVTKIFSSEFNFILEICDNLHITTVPANAFQGMNNESITLKLYGNGFEEIQSHAFNGTTLISLELKENAHLKKMHNDAFRGARGPSILDISSTKLQALPSYGLESIQTLIATSSYSLKKLPSREKFTNLLDATLTYPSHCCAFRNLPTKEQNFSFSIFKNFSKQCESTARRPNNETLYSAIFAESELSDWDYDYGFCSPKTLQCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNVTVLFVLLTSHYKLTVPRFLMCNLSFADFCMGLYLLLIASVDAQTKGQYYNHAIDWQTGNGCSVAGFFTVFASELSVYTLTVITLERWHTITYAIQLDQKLRLRHAIPIMLGGWLFSTLIAMLPLVGVSSYMKVSICLPMDVETTLSQVYILTILILNVVAFIIICACYIKIYFAVQNPELMATNKDTKIAKKMAVLIFTDFTCMAPISFFAISAALKVPLITVTNSKVLLVLFYPVNSCANPFLYAIFTKAFRRDFFLLLSKSGCCKHQAELYRRKDFSAYCKNGFTGSNKPSRSTLKLTTLQCQYSTVMDKTCYKDC
Organism_Source Sus scrofa
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names LHCGR
UniProt_ID P16582
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide 7-24
Peptide_Sequence LCPEPCSCAPDGALRCPG
Peptide_Length 18
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1789.09
Aliphatic_Index 54.44444
Aromaticity 0.00000
Average_Rotatable_Bonds 2.72222
Charge_at_pH_7 -1.24770
Isoelectric_Point 4.18428
Hydrogen_Bond_Acceptors 27
Hydrogen_Bond_Donors 25
Topological_Polar_Surface_Area 679.59000
X_logP_energy -8.62623
Interaction Information
Affinity IC50=130 uM
Affinity_Assay Radioligand binding assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Peptide and immunochemical mapping of the ectodomain of the porcine LH receptor
Release_Year 1996
PMID 8672229
DOI 10.1677/jme.0.0160015