PPIRE18526

Target Protein Information
Protein_Name Lutropin-choriogonadotropic hormone receptor
Protein_Sequence MRRRSLALRLLLALLLLPPPLPQTLLGAPCPEPCSCRPDGALRCPGPRAGLSRLSLTYLPIKVIPSQAFRGLNEVVKIEISQSDSLEKIEANAFDNLLNLSEILIQNTKNLVYIEPGAFTNLPRLKYLSICNTGIRKLPDVTKIFSSEFNFILEICDNLHITTVPANAFQGMNNESITLKLYGNGFEEIQSHAFNGTTLISLELKENAHLKKMHNDAFRGARGPSILDISSTKLQALPSYGLESIQTLIATSSYSLKKLPSREKFTNLLDATLTYPSHCCAFRNLPTKEQNFSFSIFKNFSKQCESTARRPNNETLYSAIFAESELSDWDYDYGFCSPKTLQCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNVTVLFVLLTSHYKLTVPRFLMCNLSFADFCMGLYLLLIASVDAQTKGQYYNHAIDWQTGNGCSVAGFFTVFASELSVYTLTVITLERWHTITYAIQLDQKLRLRHAIPIMLGGWLFSTLIAMLPLVGVSSYMKVSICLPMDVETTLSQVYILTILILNVVAFIIICACYIKIYFAVQNPELMATNKDTKIAKKMAVLIFTDFTCMAPISFFAISAALKVPLITVTNSKVLLVLFYPVNSCANPFLYAIFTKAFRRDFFLLLSKSGCCKHQAELYRRKDFSAYCKNGFTGSNKPSRSTLKLTTLQCQYSTVMDKTCYKDC
Organism_Source Sus scrofa
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names LHCGR
UniProt_ID P16582
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide 21-36
Peptide_Sequence RCPGPRAGLSRLSLTY
Peptide_Length 16
Peptide_SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1747.05
Aliphatic_Index 79.37500
Aromaticity 0.06250
Average_Rotatable_Bonds 3.31250
Charge_at_pH_7 2.93515
Isoelectric_Point 11.05980
Hydrogen_Bond_Acceptors 25
Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 748.86000
X_logP_energy -8.86299
Interaction Information
Affinity IC50=88 uM
Affinity_Assay Radioligand binding assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Peptide and immunochemical mapping of the ectodomain of the porcine LH receptor
Release_Year 1996
PMID 8672229
DOI 10.1677/jme.0.0160015