PPIRE18528

Target Protein Information
Protein_Name Lutropin-choriogonadotropic hormone receptor
Protein_Sequence MRRRSLALRLLLALLLLPPPLPQTLLGAPCPEPCSCRPDGALRCPGPRAGLSRLSLTYLPIKVIPSQAFRGLNEVVKIEISQSDSLEKIEANAFDNLLNLSEILIQNTKNLVYIEPGAFTNLPRLKYLSICNTGIRKLPDVTKIFSSEFNFILEICDNLHITTVPANAFQGMNNESITLKLYGNGFEEIQSHAFNGTTLISLELKENAHLKKMHNDAFRGARGPSILDISSTKLQALPSYGLESIQTLIATSSYSLKKLPSREKFTNLLDATLTYPSHCCAFRNLPTKEQNFSFSIFKNFSKQCESTARRPNNETLYSAIFAESELSDWDYDYGFCSPKTLQCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNVTVLFVLLTSHYKLTVPRFLMCNLSFADFCMGLYLLLIASVDAQTKGQYYNHAIDWQTGNGCSVAGFFTVFASELSVYTLTVITLERWHTITYAIQLDQKLRLRHAIPIMLGGWLFSTLIAMLPLVGVSSYMKVSICLPMDVETTLSQVYILTILILNVVAFIIICACYIKIYFAVQNPELMATNKDTKIAKKMAVLIFTDFTCMAPISFFAISAALKVPLITVTNSKVLLVLFYPVNSCANPFLYAIFTKAFRRDFFLLLSKSGCCKHQAELYRRKDFSAYCKNGFTGSNKPSRSTLKLTTLQCQYSTVMDKTCYKDC
Organism_Source Sus scrofa
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names LHCGR
UniProt_ID P16582
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide 25-40
Peptide_Sequence PRAGLARLSLTYLPIK
Peptide_Length 16
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1769.16
Aliphatic_Index 134.37500
Aromaticity 0.06250
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 2.99683
Isoelectric_Point 11.53052
Hydrogen_Bond_Acceptors 23
Hydrogen_Bond_Donors 26
Topological_Polar_Surface_Area 687.55000
X_logP_energy -4.52016
Interaction Information
Affinity IC50=225 uM
Affinity_Assay Radioligand binding assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Peptide and immunochemical mapping of the ectodomain of the porcine LH receptor
Release_Year 1996
PMID 8672229
DOI 10.1677/jme.0.0160015