PPIRE18534

Target Protein Information
Protein_Name Lutropin-choriogonadotropic hormone receptor
Protein_Sequence MRRRSLALRLLLALLLLPPPLPQTLLGAPCPEPCSCRPDGALRCPGPRAGLSRLSLTYLPIKVIPSQAFRGLNEVVKIEISQSDSLEKIEANAFDNLLNLSEILIQNTKNLVYIEPGAFTNLPRLKYLSICNTGIRKLPDVTKIFSSEFNFILEICDNLHITTVPANAFQGMNNESITLKLYGNGFEEIQSHAFNGTTLISLELKENAHLKKMHNDAFRGARGPSILDISSTKLQALPSYGLESIQTLIATSSYSLKKLPSREKFTNLLDATLTYPSHCCAFRNLPTKEQNFSFSIFKNFSKQCESTARRPNNETLYSAIFAESELSDWDYDYGFCSPKTLQCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNVTVLFVLLTSHYKLTVPRFLMCNLSFADFCMGLYLLLIASVDAQTKGQYYNHAIDWQTGNGCSVAGFFTVFASELSVYTLTVITLERWHTITYAIQLDQKLRLRHAIPIMLGGWLFSTLIAMLPLVGVSSYMKVSICLPMDVETTLSQVYILTILILNVVAFIIICACYIKIYFAVQNPELMATNKDTKIAKKMAVLIFTDFTCMAPISFFAISAALKVPLITVTNSKVLLVLFYPVNSCANPFLYAIFTKAFRRDFFLLLSKSGCCKHQAELYRRKDFSAYCKNGFTGSNKPSRSTLKLTTLQCQYSTVMDKTCYKDC
Organism_Source Sus scrofa
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names LHCGR
UniProt_ID P16582
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide 102-121
Peptide_Sequence RLKYLSICNTGIRKLPDVTK
Peptide_Length 20
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCCNC(=N)N)[C@@H](C)CC)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2318.81
Aliphatic_Index 112.00000
Aromaticity 0.05000
Average_Rotatable_Bonds 3.95000
Charge_at_pH_7 3.93471
Isoelectric_Point 10.63357
Hydrogen_Bond_Acceptors 33
Hydrogen_Bond_Donors 36
Topological_Polar_Surface_Area 970.60000
X_logP_energy -8.47076
Interaction Information
Affinity IC50=207 uM
Affinity_Assay Radioligand binding assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Peptide and immunochemical mapping of the ectodomain of the porcine LH receptor
Release_Year 1996
PMID 8672229
DOI 10.1677/jme.0.0160015