PPIRE18542

Target Protein Information
Protein_Name Fusion glycoprotein F0
Protein_Sequence MGSRSSTRIPVPLMLIIRTALTLSCIRLTSSLDGRPLAAAGIVVTGDKAVNIYTSSQTGSIIVKLLPNMPKDKEVCAKAPLEAYNRTLTTLLTPLGDSIRRIQESVTTSGGRRQRRFIGAIIGSVALGVATAAQITAASALIQANQNAANILRLKESIAATNEAVHEVTDGLSQLAVAVGKMQQFVNDQFNNTAQELDCIKIAQQVGVELNLYLTELTTVFGPQITSPALTQLTIQALYNLAGGNMDYLLTKLGVGNNQLSSLIGSGLITGNPILYDSQTQILGIQVTLPSVGNLNNMRATYLETLSVSTTKGFASALVPKVVTQVGSVIEELDTSYCIGTDLDLYCTRIVTFPMSPGIYSCLSGNTSACMYSKTEGALTTPYMALKGSVIANCKLTTCRCADPPGIISQNYGEAVSLIDRHSCNVLSLDGITLRLSGEFDATYQKNISILDSQVIVTGNLDISTELGNVNNSISNALNKLEESNSKLDKVNVKLTSTSALITYIVLTVISLVFGVLSLVLACYLMYKQKAQQKTLLWLGNNTLDQMRATTKI
Organism_Source Newcastle disease virus (strain Texas)
Functional_Classification fusion proteins
Cellular_Localization Plasma membrane
Gene_Names F
UniProt_ID P26628
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name WTF20
Peptide_Sequence ALDKLEESNSKLDKVNVKLT
Peptide_Length 20
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)O)[C@@H](C)O)C(C)C)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2244.57
Aliphatic_Index 112.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 4.10000
Charge_at_pH_7 0.00125
Isoelectric_Point 6.62311
Hydrogen_Bond_Acceptors 34
Hydrogen_Bond_Donors 34
Topological_Polar_Surface_Area 1016.37000
X_logP_energy -10.56300
Interaction Information
Affinity IC50=2 mM
Affinity_Assay cellell fusion assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Analysis of a Peptide Inhibitor of Paramyxovirus (NDV) Fusion Using Biological Assays NMR and Molecular Modeling
Release_Year 1997
PMID 9400602
DOI 10.1006/viro.1997.8834