PPIRE18544

Target Protein Information
Protein_Name Protein numb
Protein_Sequence MGNSSSHTHEPLERGFTRGKFGDVKNGKSASFRFSKKSPKKMDRLRRSFRDSFRRRKDRVPESSKPHQWQADEEAVRSATCSFSVKYLGCVEVFESRGMQVCEEALKVLRQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNHERGFSYICRDGTTRRWMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDTKNSTFTRTGSFRQQTLTERLAMATVGTNERSVDGPGSAMPGPPAATVKPFNPFAIERPHATPNMLERQSSFRLSTIGSQSPFKRQMSLRINDLPSNADRQRAFLTAAAGNPMQTPLRSVSPIAEVSPAKSAGADPLSAAAVAADSVSQLCQELSQGLSLLTQTDALLAAGEDLNFNNNRSINQNIIAAEKQVQHVHSYAPPTAQVTPRVASTTPTYQTLHSQSPSRSEQSIETSTELPNAEQWLGHVVRSTSPAAPKRPTYLANVGRAQTLASGTGAAVGGGGPDDPFDAEWVANVAAAKQLSPDLPIPSTARSPLARHSTNPFISPPKAPAQSFQVQL
Organism_Source Drosophila melanogaster
Functional_Classification PTB domain containing proteins
Cellular_Localization Cytoplasm
Gene_Names numb
UniProt_ID P16554
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Lnx
Peptide_Sequence EPGLDNPAYTSSVE
Peptide_Length 14
Peptide_SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1478.53
Aliphatic_Index 55.71429
Aromaticity 0.07143
Average_Rotatable_Bonds 3.07143
Charge_at_pH_7 -2.99887
Isoelectric_Point 3.42471
Hydrogen_Bond_Acceptors 23
Hydrogen_Bond_Donors 21
Topological_Polar_Surface_Area 659.95000
X_logP_energy -8.54010
Interaction Information
Affinity KD=1.79 mM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity
Release_Year 1998
PMID 9846878
DOI 10.1038/4185