PPIRE18598

Target Protein Information
Protein_Name PC4 and SFRS1-interacting protein
Protein_Sequence MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETEISLKDSTLDN
Organism_Source Homo sapiens
Functional_Classification histone methyllysine reader
Cellular_Localization Nucleus
Gene_Names PSIP1
UniProt_ID O75475
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name H3A3
Peptide_Sequence SAPATGGVXKPAAYAPG
Peptide_Length 17
Peptide_SMILES CC(C)[C@H](NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@@H](N)CO)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O
Chemical_Modification X9=trimethyllysine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1471.63
Aliphatic_Index 46.47059
Aromaticity 0.05882
Average_Rotatable_Bonds 2.29412
Charge_at_pH_7 0.99684
Isoelectric_Point 9.29830
Hydrogen_Bond_Acceptors 22
Hydrogen_Bond_Donors 19
Topological_Polar_Surface_Area 589.26000
X_logP_energy -8.59480
Interaction Information
Affinity KD=13.3 mM
Affinity_Assay NMR chemical shift perturbation
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Mimicking the Nucleosomal Context in Peptide-Based Binders of a H3K36me Reader Increases Binding Affinity While Altering the Binding Mode
Release_Year 2020
PMID 33114657
DOI 10.3390/molecules25214951