PPIRE18619
Target Protein Information
| Protein_Name | T cell receptor alpha variable 12-2 |
|---|---|
| Protein_Sequence | MKSLRVLLVILWLQLSWVWSQQKEVEQNSGPLSVPEGAIASLNCTYSDRGSQSFFWYRQYSGKSPELIMFIYSNGDKEDGRFTAQLNKASQYVSLLIRDSQPSDSATYLCAVN |
| Organism_Source | Homo sapiens |
| Functional_Classification | T cell receptors |
| Cellular_Localization | Plasma membrane |
| Gene_Names | TRAV12-2 |
| UniProt_ID | A0A075B6T6 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | SMLGIGIVPV |
|---|---|
| Peptide_Sequence | SMLGIGIVPV |
| Peptide_Length | 10 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CO)C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)C(C)C)C(C)C)[C@@H](C)CC |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 985.25 |
|---|---|
| Aliphatic_Index | 175.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.00000 |
| Charge_at_pH_7 | -0.00202 |
| Isoelectric_Point | 6.10000 |
|---|---|
| Hydrogen_Bond_Acceptors | 13 |
| Hydrogen_Bond_Donors | 11 |
| Topological_Polar_Surface_Area | 336.66000 |
| X_logP_energy | -1.27380 |
Interaction Information
| Affinity | KD=200 uM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | T cell receptor cross-reactivity expanded by dramatic peptide-鍌欒兌閸嬨劑宕曢懠韬蹭汗闁革附 adaptability |
| Release_Year | 2018 |
| PMID | 30224695 |
| DOI | 10.1038/s41589-018-0130-4 |