PPIRE18636
Target Protein Information
| Protein_Name | None |
|---|---|
| Protein_Sequence | MVPGPVALSSAYCSASEFQSDKKSLPVVETERKRRQLAHSCPGDCGRRKMARAVCPLNALWLLEWVQLFLGPGAIPLGWALNLDPVQLTFYTGPNGSHFGFSLDFYKDNHGRVAFVVGAPRTLGRSQEETGGVFLCPWRAEGGQCTSLPFDLNDETRHIGSHTFQTFKSRQGLGASVVSWNDNIVACAPWQHWNVLEKTEEAEKTPVGGCFVAQLRNGHRAEYSPCRANTMSSVYVKNRFNQDKRYCEAGFSAAVTQAGVLVLGAPGGYFFLGLLVRTPIDNIISSYRPGTLLWHVSSQSFTYDYSKPEYYDGYRGYSVAVGEFDGNLNTTEYVLGAPTWSCTLGAVEILNEYHQTLHRLHGEQMASYFGHSIAVTDVNGDGRHDLLVGAPLFMESRADRKLAEVGRVYLFLQPRGHQALGAPSLLLTGTQLYGRFGSAIASLGDLDRDGYNDVAVAAPYGGPSSLGQVLVYLGQSEGLSSRPSQILDSPFPAGSGFGFSLRGATDIDDNGYPDLLVGAYGASKVAVYRAQPVVVANVQLLVQDSLNPAVKNCILPQTKTPVSCFNIQMCMGATGHNIPQQLPLNAELQLDRQKPRQGRRVLLLNSQLASSTLHLDLGGRHSPICHTTTAFLRDEADFRDKLSPIVLSLNVSLQPGKDGVAPAIVLHGDTHVQEQTRIILDCGEDDLCVPQLQLTAIVMGSPLLIGADNVLELQMDAANEGEGAYEAELAVHLPPGAHYMRAISNIEGFERLICNQKKENETKIVLCELGNPMKRNARIGITMLVSVENLEEAGEHVSFWLQIRSKNSQNPNSEAVLLDVPVRAEAHVKLRGNSFPASLVVVAEEDNRENSSESWGPKVEHTYELHNNGPGTVSGLHLHLCFPGESQPSDLLYILDIQPEGGLQCSPQPSINPFKLDWRQPTPSPSPTSPGYHKRERRQASLPGSSQPSGLQDPVLLSCKSGPHTVVQCELQEMARGQRAMVKVLAFLQLPSLQQRPLDQFVLESQAWFNVSSLPYAVPSLSLPSGETLVQTHLLRALEERDIPIWWVLVGVLGGLLLLMLLVLAMWKGGFFKRNRPPLEEEEEE |
| Organism_Source | Canis lupus familiaris |
| Functional_Classification | integrins |
| Cellular_Localization | Plasma membrane |
| Gene_Names | ITGA2B |
| UniProt_ID | A0A8I3RVR5 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | H-Gly-Pen-Gly-Arg-Gly-Asp-Ser-Pro-Cys-Ala-OH |
|---|---|
| Peptide_Sequence | GXGRGDSCPA |
| Peptide_Length | 10 |
| Peptide_SMILES | C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)CN)C(=O)O |
| Chemical_Modification | X2=penicillamine |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 875.91 |
|---|---|
| Aliphatic_Index | 10.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 2.60000 |
| Charge_at_pH_7 | -0.06355 |
| Isoelectric_Point | 6.16117 |
|---|---|
| Hydrogen_Bond_Acceptors | 15 |
| Hydrogen_Bond_Donors | 16 |
| Topological_Polar_Surface_Area | 435.86000 |
| X_logP_energy | -8.52673 |
Interaction Information
| Affinity | IC50=10.1 uM |
|---|---|
| Affinity_Assay | platelet aggregation assay |
| PDB_ID | None |
| Type | Antagonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Investigation of Conformational Specificity at GPIIb/IIIa: Evaluation of Conformationally Constrained RGD Peptides |
| Release_Year | 1992 |
| PMID | 1619619 |
| DOI | 10.1021/jm00091a013 |