PPIRE18639

Target Protein Information
Protein_Name None
Protein_Sequence MVPGPVALSSAYCSASEFQSDKKSLPVVETERKRRQLAHSCPGDCGRRKMARAVCPLNALWLLEWVQLFLGPGAIPLGWALNLDPVQLTFYTGPNGSHFGFSLDFYKDNHGRVAFVVGAPRTLGRSQEETGGVFLCPWRAEGGQCTSLPFDLNDETRHIGSHTFQTFKSRQGLGASVVSWNDNIVACAPWQHWNVLEKTEEAEKTPVGGCFVAQLRNGHRAEYSPCRANTMSSVYVKNRFNQDKRYCEAGFSAAVTQAGVLVLGAPGGYFFLGLLVRTPIDNIISSYRPGTLLWHVSSQSFTYDYSKPEYYDGYRGYSVAVGEFDGNLNTTEYVLGAPTWSCTLGAVEILNEYHQTLHRLHGEQMASYFGHSIAVTDVNGDGRHDLLVGAPLFMESRADRKLAEVGRVYLFLQPRGHQALGAPSLLLTGTQLYGRFGSAIASLGDLDRDGYNDVAVAAPYGGPSSLGQVLVYLGQSEGLSSRPSQILDSPFPAGSGFGFSLRGATDIDDNGYPDLLVGAYGASKVAVYRAQPVVVANVQLLVQDSLNPAVKNCILPQTKTPVSCFNIQMCMGATGHNIPQQLPLNAELQLDRQKPRQGRRVLLLNSQLASSTLHLDLGGRHSPICHTTTAFLRDEADFRDKLSPIVLSLNVSLQPGKDGVAPAIVLHGDTHVQEQTRIILDCGEDDLCVPQLQLTAIVMGSPLLIGADNVLELQMDAANEGEGAYEAELAVHLPPGAHYMRAISNIEGFERLICNQKKENETKIVLCELGNPMKRNARIGITMLVSVENLEEAGEHVSFWLQIRSKNSQNPNSEAVLLDVPVRAEAHVKLRGNSFPASLVVVAEEDNRENSSESWGPKVEHTYELHNNGPGTVSGLHLHLCFPGESQPSDLLYILDIQPEGGLQCSPQPSINPFKLDWRQPTPSPSPTSPGYHKRERRQASLPGSSQPSGLQDPVLLSCKSGPHTVVQCELQEMARGQRAMVKVLAFLQLPSLQQRPLDQFVLESQAWFNVSSLPYAVPSLSLPSGETLVQTHLLRALEERDIPIWWVLVGVLGGLLLLMLLVLAMWKGGFFKRNRPPLEEEEEE
Organism_Source Canis lupus familiaris
Functional_Classification integrins
Cellular_Localization Plasma membrane
Gene_Names ITGA2B
UniProt_ID A0A8I3RVR5
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name cyclo(D-Phe-Pro-Arg-Gly-Asp)2
Peptide_Sequence fPRGDfPRGD
Peptide_Length 10
Peptide_SMILES N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method multi-point cyclization; f1<-->D5; amide bond; f6<-->D10; amide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1163.26
Aliphatic_Index 0.00000
Aromaticity 0.20000
Average_Rotatable_Bonds 3.30000
Charge_at_pH_7 -0.00113
Isoelectric_Point 6.45000
Hydrogen_Bond_Acceptors 15
Hydrogen_Bond_Donors 17
Topological_Polar_Surface_Area 506.04000
X_logP_energy -5.00196
Interaction Information
Affinity IC50=200 uM
Affinity_Assay platelet aggregation assay
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Research Articles
Title Investigation of Conformational Specificity at GPIIb/IIIa: Evaluation of Conformationally Constrained RGD Peptides
Release_Year 1992
PMID 1619619
DOI 10.1021/jm00091a013