PPIRE18642
Target Protein Information
| Protein_Name | Microtubule-associated protein 1 light chain 3 alpha |
|---|---|
| Protein_Sequence | MPSDRPFKQRRSFADRCKEVQQIRDQHPSKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELVKIIRRRLQLNPTQAFFLLVNQHSMVSVSTPIADIYEQEKDEDGFLYMVYASQETFGF |
| Organism_Source | Homo sapiens |
| Functional_Classification | Cytoskeletal microtubule associated proteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | MAP1LC3A |
| UniProt_ID | Q9H492 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | p62 LIR peptide |
|---|---|
| Peptide_Sequence | SGGDDDWTHLSSKEVD |
| Peptide_Length | 16 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CO)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)O)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | FITC |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1747.75 |
|---|---|
| Aliphatic_Index | 42.50000 |
| Aromaticity | 0.06250 |
| Average_Rotatable_Bonds | 3.56250 |
| Charge_at_pH_7 | -3.90784 |
| Isoelectric_Point | 3.88351 |
|---|---|
| Hydrogen_Bond_Acceptors | 28 |
| Hydrogen_Bond_Donors | 29 |
| Topological_Polar_Surface_Area | 837.73000 |
| X_logP_energy | -11.42470 |
Interaction Information
| Affinity | KD=37 nM |
|---|---|
| Affinity_Assay | time-resolved fluorescence resonance energy transfer |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | LIR peptide selectivity for ATG8 homologs |
| Release_Year | 2019 |
| PMID | 31362979 |
| DOI | 10.1074/jbc.RA119.008723 |