PPIRE18662
Target Protein Information
| Protein_Name | Alpha-synuclein |
|---|---|
| Protein_Sequence | MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA |
| Organism_Source | Homo sapiens |
| Functional_Classification | amyloid proteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | SNCA |
| UniProt_ID | P37840 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | WT |
|---|---|
| Peptide_Sequence | GSKTKEG |
| Peptide_Length | 7 |
| Peptide_SMILES | C[C@@H](O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | 3-MPA |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 705.77 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.71429 |
| Charge_at_pH_7 | 0.99917 |
| Isoelectric_Point | 9.53730 |
|---|---|
| Hydrogen_Bond_Acceptors | 13 |
| Hydrogen_Bond_Donors | 13 |
| Topological_Polar_Surface_Area | 367.72000 |
| X_logP_energy | -5.93420 |
Interaction Information
| Affinity | KD=0.229 nM |
|---|---|
| Affinity_Assay | electrochemical impedance spectroscopy |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Electrochemical flow injection analysis of the interaction between pyrroloquinoline quinone (PQQ) and Alpha-synuclein peptides related to Parkinson-鍌欒兌閸嬨劑宕曢弻銉﹀仒 disease |
| Release_Year | 2021 |
| PMID | 34251376 |
| DOI | 10.1039/d1an00698c |