PPIRE18665

Target Protein Information
Protein_Name HLA class II histocompatibility antigen DM alpha chain
Protein_Sequence MGHEQNQGAALLQMLPLLWLLPHSWAVPEAPTPMWPDDLQNHTFLHTVYCQDGSPSVGLSEAYDEDQLFFFDFSQNTRVPRLPEFADWAQEQGDAPAILFDKEFCEWMIQQIGPKLDGKIPVSRGFPIAEVFTLKPLEFGKPNTLVCFVSNLFPPMLTVNWQHHSVPVEGFGPTFVSAVDGLSFQAFSYLNFTPEPSDIFSCIVTHEIDRYTAIAYWVPRNALPSDLLENVLCGVAFGLGVLGIIVGIVLIIYFRKPCSGD
Organism_Source Homo sapiens
Functional_Classification MHC class 2 molecules
Cellular_Localization Plasma membrane
Gene_Names HLA-DMA
UniProt_ID P28067
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CLIP
Peptide_Sequence VSKMRMATPLLMQ
Peptide_Length 13
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1505.92
Aliphatic_Index 90.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.92308
Charge_at_pH_7 1.99769
Isoelectric_Point 11.65178
Hydrogen_Bond_Acceptors 22
Hydrogen_Bond_Donors 20
Topological_Polar_Surface_Area 575.20000
X_logP_energy -4.21963
Interaction Information
Affinity KD=0.7 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange
Release_Year 2011
PMID 22084083
DOI 10.1073/pnas.1108074108