PPIRE18680

Target Protein Information
Protein_Name Glyceraldehyde-3-phosphate dehydrogenase
Protein_Sequence MVKVGVNGFGRIGRLVTRAAFNSGKVDVVAINDPFIDLHYMVYMFQYDSTHGKFHGTVKAENGKLVINGKAITIFQERDPANIKWGDAGAEYVVESTGVFTTMEKAGAHLKGGAKRVIISAPSADAPMFVMGVNHEKYDNSLKIVSNASCTTNCLAPLAKVIHDHFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGAAQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTPNVSVVDLTCRLEKAAKYDDIKKVVKQASEGPLKGILGYTEDQVVSCDFNSATHSSTFDAGAGIALNDHFVKLISWYDNEFGYSNRVVDLMVHMASKE
Organism_Source Oryctolagus cuniculus
Functional_Classification dehydrogenases
Cellular_Localization Cytoplasm
Gene_Names GAPDH
UniProt_ID P46406
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name B3P
Peptide_Sequence MEELQDDYEDMMEEN
Peptide_Length 15
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1921.01
Aliphatic_Index 26.00000
Aromaticity 0.06667
Average_Rotatable_Bonds 4.53333
Charge_at_pH_7 -7.99265
Isoelectric_Point 3.04983
Hydrogen_Bond_Acceptors 30
Hydrogen_Bond_Donors 27
Topological_Polar_Surface_Area 875.53000
X_logP_energy -7.67180
Interaction Information
Affinity Ki=210 uM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID 3BTB
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Insights into Tyrosine Phosphorylation Control of Protein-Protein Association from the NMR Structure of a Band 3 Peptide Inhibitor Bound to Glyceraldehyde-3-phosphate Dehydrogenase
Release_Year 1998
PMID 9454576
DOI 10.1021/bi971445b